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6-(2-aminopropyl)benzofuran or 1-benzofuran-6-ylpropan-2-amine (6-APB or Benzo Fury[1][2]) is a stimulant and entactogen drug . It was first identified being sold as a designer drug in 2011,[3] and again in 2012.[4] Chemically, it is of the phenethylamine and substituted amphetamine classes. It is similar to MDA in that the 3,4-methylenedioxyphenyl ring system has been replaced with a benzofuran ring. 6-APB is also the unsaturated benzofuran derivative of 6-APDB. There is currently no toxicology data available.
6-APB has not been properly assessed in terms of pharmacological action, but based on its chemical similarity to other amphetamines and methylenedioxy compounds, it likely acts as a releasing agent and reuptake inhibitor of serotonin, norepinephrine, and dopamine.[citation needed] Though its effects on monoamine release have not been validated, 6-APB has been claimed to act as an agonist of the 5-HT2C receptor.[5] It may also act as an agonist of the 5-HT2A and 5-HT2B receptors, the former likely explaining its reputed psychedelic effects.
6-APB is not listed under the Opium Law or the Medicine Act in the Netherlands, and thus currently legal.
6-APB is unscheduled in the United States. However, this chemical may be covered under the Federal Analogue Act in the United States.
Certain countries contain a "substantially similar" catch-all clause in their drug law, such as New Zealand and Australia. This includes 6-APB as it is in some respects similar in chemical structure to the class A drug MDA[citation needed], meaning 6-APB may be viewed as a controlled substance analogue in these jurisdictions.[6]
6-APB is unscheduled under the Controlled Drugs and Substances Act (CDSA) in Canada, although there is a Schedule III amphetamine analogue clause. Due to 6-APB's structure, it may be considered an analogue of MDA, but these types of offenses are rarely prosecuted.[citation needed] Canada's CDSA defines an analogue as any substance that, in relation to a controlled substance, has a substantially similar chemical structure.
6-APB is currently legal in the United Kingdom.
| Systematic (IUPAC) name | |
|---|---|
| 6-(2-aminopropyl)benzofuran | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 286834-85-3 286834-84-2 (hydrochloride) |
| ATC code | None |
| PubChem | CID 9794343 |
| ChemSpider | 7970110 |
| Chemical data | |
| Formula | C11H13NO |
| Mol. mass | 175.23 g/mol |
| SMILES | eMolecules & PubCh |